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Upon activation, NLRP3 engages the scaffold protein NIMA related kinase 7 (NEK7) and recruits the adaptor apoptosis-associated speck-like protein containing a CARD (PYD and CARD domain containing (PYCARD, also known as ASC)) to assemble the inflammasome complex

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The relevance here is evidential, not procedural: because delivery and stability vary so much, comparing results across products and studies is genuinely difficult, and that heterogeneity is one reason a clean answer to the title question has been so slow to emerge